Cardiovascular Disease
Cardiovascular diseases have become an epidemic across the globe. New research and therapies regarding cardiovascular disease have been in progress. Hence, we promote those researching by providing services and facilities that will help you in advancing your R&D. We have an array of disease models that can be customized as per your study plans. Our expert team will assist you with preclinical risk assessment services, toxicology tests, cytoprotective studies and other related services.
Discovery Services
- Cardioprotective studies
- Hypertrophic cardiomyopathy related studies
- Myocardial Infarction based studies
- Atrial fibrillation (AF) (cardiac arrhythmia) based studies
- hERG : Patch-clamp assay
- hERG serum shift assays
- Ion channel trafficking assay
- Action potential duration (ADP) assays
- Cardiac marker detection: Troponin I, II
- Integrated human cardiomyocyte assays
- Hit Identification
- High content imaging- analysis of drug interaction at the sub-cellular level
Available Models
Human primary cell-based assays- using 2D and 3D disease-relevant models. High Content Screening- using standard cell model and disease-related cell lines.
3D model
- 3D microtissue- Human mesenchymal stem cell-derived cardiomyocytes (hMSCs-CMs)
- Spheroids- induced pluripotent stem cell derived cardiomyocytes (iPSCs - CMs)
- Cardiac endothelial cells
- Cardiac fibroblasts
- Heart-on-Chip
2D model
- hERG stably transfected HEK293 cells
- Human mesenchymal stem cell-derived cardiomyocytes (hMSCs-CMs)
- induced Pluripotent Stem Cell (iPSC) derived cardiomyocytes
- H9C2 cell line
Techniques Used
Electrophysiology, Flow Cytometry, High Content Imaging to analyse drug interaction at the sub-cellular level, Confocal/Fluorescence Microscopy(Multi-colour Immunofluorescence), ELISA (Fluorimetry/Colorimetry) RTqPCR,WB.