Immunology
When dealing with immune drug discovery therapies, there happen to be multiple areas that cover immunology research, such as inflammation and autoimmune disease, which are part of the immune study. We conduct primary cell assays that enable us to know the efficacy and mechanism of action of the drug at cellular level. Stellixir Biotech uses in vitro studies that reduce costs and shifting of attrition in the early stages. These testing methods gives an opportunity for de-risking the progression and preventing the usage of in vivo models.
Discovery Services
In-Vitro Immunology Assays for Drug Screening:
Determines mechanism of action, screen compounds, validate biomarkers, and provide predictive immunotoxicology using following assays:
- Fibroblast-like synoviocyte activation assay
- Chemotaxis assay: Monocytes
- Chemotaxis assay: Neutrophils
- Conventional Dendritic cells activation assay
- Plasmacytoid Dendritic cells activation assay
- Anti-inflammatory assays
- Immunomodulatory assays
Available Models
- THP1 cell lines
- Human and rodent Peripheral Blood Mononuclear cells
- Human and rodent T cells
- Human and rodent Neutrophils
- Human and rodent Dendritic Cells
- Human and rodent Macrophages
Clinical Immunology Assays
- Flow cytometry for PK/PD
- Flow cytometry for CD marker analysis of immune cells
- ELISpot, to evaluate cellular immune response
- Multiplex cytokine analyses
Techniques Used: Flow Cytometry (Intra and extra cellular cytokines), Confocal/Fluorescence Microscopy (Multi-colour Immunofluorescence), ELISA (Fluorimetry/Colorimetry) RTqPCR, WB.