Solutions

Stellixir Biotech has a specialized toxicology program that aims at various products. These products include pharmaceuticals, biopharmaceuticals, biologics, and chemicals whose test results are compared with the regulated historical database. Equipped with technical personnel and qualified scientists who have expertise in neurotoxicology will know the required screening tests and make a note of on or off-target effects. They will work on target tissue delivery, extensively enabling investigative studies. These evaluations can give an insight into developmental neurotoxicity and promote preclinical study. The indications are worth noting as they provide an analysis of abuse and results of dependence liability potential.

In Vitro Assays for Neurotoxicity

• Developmental neurotoxicity
• Neurite outgrowth
• Synaptogenesis assay

Neurotoxicity Assays

• Neurobehavior, including assays of locomotor activity, rotarod forced activity, water maze learning and memory testing, auditory startle habituation, and functional observational batteries
• Abuse liability testing with any drug that crosses the blood-brain barrier regardless of a therapeutic indication
• Ototoxicity testing, GLP-compliant and measuring auditory function, cytocochleogram, otic histology, and evaluation of potential recovery
• Neurochemistry, including cholinesterase assays in red blood cell, plasma, and brain samples, as well as quantification of endogenous levels of neurotransmitters
• Neuropathology, including in situ perfusion, morphometry, stereology, and qualitative neuropathological evaluations

Assessment of Neurotoxicity

• Acute neurotoxicity
• Sub chronic neurotoxicity
• Developmental neurotoxicity
• Behavioral and developmental toxicity
• Safety pharmacology
• NMDA receptor antagonist