Endocrine Disruption Screening
Endocrine disruptors are chemicals that can interfere with endocrine (or hormone) systems in the body. Chemicals with estrogenic effects can be found in everyday life because of low doses of endocrine disrupting chemicals in thousands of products such as metal food cans, plastic bottles, detergents, flame retardants, toys, cosmetics and pesticides. Endocrine disrupting chemicals that are commonly detected in people include DDT, polychlorinated biphenyls (PCB's), bisphenol A (BPA), polybrominated diphenyl ethers (PBDE's), diethylstilbestrol, and phthalates.
In the past years, more and more evidence showed that adverse effects exist in humans and wildlife when exposed to chemicals which can disrupt the endocrine system. Stellixir, offers consistent and cost-effective endocrine disruption screening service. We support researchers to determine whether exposure to endocrine disruptors may lead to human health effects such as lowered fertility, increased incidence of endometriosis, and some cancers. With multiple specialists and years of experience in this area, we guarantee you quality data and customized results to meet your project requirements. Our scientific and regulatory experts can help with endocrine disruptor assessments according to the criteria and strategy as outlined in the ECHA/EFSA guidance.
Discovery Services:
- Estrogen Receptor (ER) Transactivation
- Androgen Receptor (AR) Transactivation
- Androgen Receptor (AR) Modulation
- Estrogen Receptor-alpha (ER-α) Binding
- Estrogen Receptor beta (ER-β) Binding
- Androgen Receptor (AR) Binding
- Steroidogenesis
- Aromatase Assay
Techniques Used: Flow Cytometry, Confocal/Fluorescence Microscopy (Multi-colour Immunofluorescence), ELISA (Fluorimetry/Colorimetry), RTqPCR, WB.