Solutions

Our clients can be assured of getting multiparametric toxicity assessment services from our lab and our esteemed team of scientists enabling the process. At Stellixir Biotech, we have believed that customizing as per the researcher's needs will enable catering to better drug development and discovery and help create alternate solutions and give data for further research. We could club in the important toxicity tests or let you pick the ones you deem fit for your study. Some of the commonly used toxicity tests are cardiotoxicity, hepatotoxicity and neurotoxicity. We take on the process by collecting biological samples, testing and assessing the results. Our team performs multiplexed cell-based assays inclusive of cytotoxicity to provide safer leads with the help of our screening panel using the latest technology.

Stellixir Biotech Multiparametric Toxicity Assessment Services

• Increased chances of predictability for clinical hepatotoxicity (sensitivity of 70% and specificity of 100%)
• Extended panel for checking the toxicologically-relevant endpoints in both replicating (HepG2) and ensuring that they are metabolically competent (rat primary hepatocytes) cells
• Multiple time points are used to investigate and identify early and late-stage toxicities
• Integration of actual or predicted Cmax data which can be used for correction in exposure-related effects
• Common toxicity signatures can be used to assess SAR sets and pick out candidates with the lowest risk for further development

In Vitro Toxicity Solutions by Stellixir Biotech

• IC50 determination
• Cell loss/death using fluorescent imaging
• Nuclear size and morphology using fluorescent imaging
• Cell membrane permeability using fluorescent imaging

We use more than 50 different cell lines of human origin for cytotoxicity testing for your research study.