Solutions

Metabolic disorders are caused when biochemicals in the body awry cause diseases related to the metabolism of the body manifesting in a variety of symptoms. Endocrine disorders and metabolic diseases often hamper the regulation of several body functions, which are complex in nature. Metabolic disorders can also be genetic in nature. Stellixir metabolism assay services has a complete set of indicators and a wide range of applications, including Enzymes, Oxidative stress, Liver biomarkers, Kidney biomarkers, Amino acids & proteins, Glycolysis & Carbohydrates, Inorganic ions, Lipids metabolism, Plant stress resistance, Tricarboxylic Aci(TCA)Cycle, etc. Stellixir Biotech enables the analysis of compounds and agents for testing various conditions.

Targeted Diseases: Diabetes and diabetic complications such as kidney disease, NASH, obesity, hypertension, thyroid, cholesterol & lipid disorders, bone disease and other metabolic disorders.

ANTI-DIABETES

Discovery Services:

• Cell proliferation studies
• Glucose uptake assay
• Alpha-amylase inhibition assay
• Alpha-glucosidase inhibition assay
• Insulin receptor binding studies
• IGF-R1 receptor binding studies
• Skeletal muscle regeneration assays using stem cells models
• Assays monitoring the protection of human podocytes or freshly isolated glomeruli
• Assays measuring anti-fibrotic effects across different primary cell types
• A comprehensive set of primary islet cell assays covering all relevant aspects of pancreatic beta-cell turnover and function
• Protection/reversal of metabolic stress-induced beta-cell de-differentiation
• Cell-specific primary rat and human beta cell replication (plated or intact islets)
• Cell-specific quantification of beta-cell apoptosis in plated islets
• Insulin secretion studies with rat and human islets

Available Models:

• 2D and 3D models of Human/Rat/Mouse cell lines: PANC1, RIN, MIN, SAOS2, HepG2.
• Stem cell models by using MSCs, and iPSCs
• Primary hepatocytes

Techniques Used: Flow Cytometry, Confocal/Fluorescence Microscopy (Multi-colour Immunofluorescence), ELISA (Fluorimetry/Colorimetry), RTqPCR, WB.